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KMID : 1007520120210051501
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Food Science and Biotechnology
2012 Volume.21 No. 5 p.1501 ~ p.1506
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Arabinogalactan-type Polysaccharides (APS) from Cordyceps militaris Grown on Germinated Soybeans (GSC) Induces Innate Immune Activity of THP-1 Monocytes through Promoting Their Macrophage Differentiation and Macrophage Activity
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Park Dong-Ki
Hayashi Toshimitsu
Park Hye-Jin
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Abstract
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In this study, the immunemodulatory activities of arabinogalactans-type polysaccharide (APS) from Cordyceps militaris grown on germinated soybeans was evaluated in THP-1 human monocytes. The cellular size and the number of intracellular organelles of THP-1 monocytes were increased by APS. Also, APS-treated THP-1 cells significantly developed cellular adherence and macrophagic differentiation to the culture plate surface. APS noticeably enhanced phagocytic activity of THP-1 cells against IgG-FITC-latex beads. APS induced the level of TNF-α, IL-12 p40, and IL-8 as well as TLR2 and TLR4 mRNAs. APS can be developed as a promising immunmodulating agent with macrophage-activating properties.
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KEYWORD
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arabinogalactans-type polysaccharide (APS), innate immunity, phagocytosis, macrophage differentiation, THP-1 monocyte
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